Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI033292-12
Application #
6631943
Study Section
Special Emphasis Panel (NSS)
Program Officer
Wassef, Nabila M
Project Start
1992-07-01
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
12
Fiscal Year
2003
Total Cost
$498,748
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Sok, Devin; Pauthner, Matthias; Briney, Bryan et al. (2016) A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans. Immunity 45:31-45
Jardine, Joseph; Julien, Jean-Philippe; Menis, Sergey et al. (2013) Rational HIV immunogen design to target specific germline B cell receptors. Science 340:711-6
Julien, Jean-Philippe; Sok, Devin; Khayat, Reza et al. (2013) Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS Pathog 9:e1003342
Gavrilyuk, Julia; Ban, Hitoshi; Uehara, Hisatoshi et al. (2013) Antibody conjugation approach enhances breadth and potency of neutralization of anti-HIV-1 antibodies and CD4-IgG. J Virol 87:4985-93
Ahmed, Fatima K; Clark, Brenda E; Burton, Dennis R et al. (2012) An engineered mutant of HIV-1 gp120 formulated with adjuvant Quil A promotes elicitation of antibody responses overlapping the CD4-binding site. Vaccine 30:922-30
Doria-Rose, Nicole A; Georgiev, Ivelin; O'Dell, Sijy et al. (2012) A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies. J Virol 86:8319-23
Falkowska, Emilia; Ramos, Alejandra; Feng, Yu et al. (2012) PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4. J Virol 86:4394-403
Burton, Dennis R; Hessell, Ann J; Keele, Brandon F et al. (2011) Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody. Proc Natl Acad Sci U S A 108:11181-6
Pejchal, Robert; Doores, Katie J; Walker, Laura M et al. (2011) A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science 334:1097-103
Agrawal, Nitish; Leaman, Daniel P; Rowcliffe, Eric et al. (2011) Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1). PLoS One 6:e21339

Showing the most recent 10 out of 107 publications