Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI034098-14
Application #
7096562
Study Section
Special Emphasis Panel (NSS)
Program Officer
Gondre-Lewis, Timothy A
Project Start
1993-03-01
Project End
2008-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
14
Fiscal Year
2006
Total Cost
$359,231
Indirect Cost
Name
Yale University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
McCurley, Nathanael; Mellman, Ira (2010) Monocyte-derived dendritic cells exhibit increased levels of lysosomal proteolysis as compared to other human dendritic cell populations. PLoS One 5:e11949
Reig, Nuria; Jiang, Aimin; Couture, Rachael et al. (2008) Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin. Cell Microbiol 10:1190-207
Di Pucchio, Tiziana; Chatterjee, Bithi; Smed-Sorensen, Anna et al. (2008) Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat Immunol 9:551-7
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Jiang, Aimin; Bloom, Ona; Ono, Satoru et al. (2007) Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity 27:610-24
Unternaehrer, Julia J; Chow, Amy; Pypaert, Marc et al. (2007) The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface. Proc Natl Acad Sci U S A 104:234-9
Shim, Jae-Hyuck; Xiao, Changchun; Hayden, Matthew S et al. (2006) CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol 172:1045-56
Yan, Jun; Wolff, Martin J; Unternaehrer, Julia et al. (2005) Targeting antigen to CD19 on B cells efficiently activates T cells. Int Immunol 17:869-77
Chow, Amy Y; Mellman, Ira (2005) Old lysosomes, new tricks: MHC II dynamics in DCs. Trends Immunol 26:72-8
Delamarre, Lelia; Pack, Margit; Chang, Henry et al. (2005) Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science 307:1630-4

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