Abstract

EXCEED THE SPACE PROVIDED. Please see p. 32. PERFORMANCE SITE(S) (organization, city, state) Center for Advanced Research in Biotechnology (CARB) University of Maryland Biotechnology Institute 9600 Gudelsky Drive Rockville, MD 20850 KEY PERSONNEL. See instructions; Use continuation pages as needed to provide the required information Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Roy A. Mariuzza CARB Yili Li CARB Rongjin Guan CARB Ries Langley CARB Chittoor P, Swaminathan CARB Roland Martin NINDS/NIH Suzanne L. Topalian NCI/NIH Jenny E. Gumperz University of Wisconsin in the format shown below. Role on Project Principal Investigator Research Associate Research Associate Research Associate Research Associate Collaborator Collaborator Collaborator Disclosure Permission Statement. Applicable to SBIR/STTR Only. See instructions. [] Yes [] No PHS 398 (Rev. 05/01 ) Page 2 Number pages consecutively at the bottom throughout Forlm Page 2 the application. Do not use suffixes such as 2a, 2b. ========================================Section End===========================================

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI036900-11
Application #
6834762
Study Section
Special Emphasis Panel (NSS)
Program Officer
Kehn, Patricia J
Project Start
1995-09-01
Project End
2010-05-31
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
11
Fiscal Year
2005
Total Cost
$334,125
Indirect Cost

  Institution

Name
University of MD Biotechnology Institute
Department
Type
Organized Research Units
DUNS #
603819210
City
Baltimore
State
MD
Country
United States
Zip Code
21202

  Publications

Yang, Xinbo; Chen, Guobing; Weng, Nan-Ping et al. (2017) Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope. J Biol Chem 292:18618-18627
Chen, Guobing; Yang, Xinbo; Ko, Annette et al. (2017) Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral Antigens. Cell Rep 19:569-583
Li, Yili; Pierce, Brian G; Wang, Qian et al. (2015) Structural basis for penetration of the glycan shield of hepatitis C virus E2 glycoprotein by a broadly neutralizing human antibody. J Biol Chem 290:10117-25
He, Yanan; Rangarajan, Sneha; Kerzic, Melissa et al. (2015) Identification of the Docking Site for CD3 on the T Cell Receptor ? Chain by Solution NMR. J Biol Chem 290:19796-805
Yang, Xinbo; Gao, Mingming; Chen, Guobing et al. (2015) Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope. J Biol Chem 290:29106-19
Rangarajan, Sneha; Mariuzza, Roy A (2014) T cell receptor bias for MHC: co-evolution or co-receptors? Cell Mol Life Sci 71:3059-68
Holland, Stephen J; Gao, Mingming; Hirano, Masayuki et al. (2014) Selection of the lamprey VLRC antigen receptor repertoire. Proc Natl Acad Sci U S A 111:14834-9
Li, Yili; Yin, Yiyuan; Mariuzza, Roy A (2013) Structural and biophysical insights into the role of CD4 and CD8 in T cell activation. Front Immunol 4:206
Deng, Lu; Luo, Ming; Velikovsky, Alejandro et al. (2013) Structural insights into the evolution of the adaptive immune system. Annu Rev Biophys 42:191-215
Luo, Ming; Velikovsky, C Alejandro; Yang, Xinbo et al. (2013) Recognition of the Thomsen-Friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor. J Biol Chem 288:23597-606

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