Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI050872-18
Application #
9456580
Study Section
Special Emphasis Panel (NSS)
Program Officer
Singleton, Kentner L
Project Start
2002-01-01
Project End
2022-03-31
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
18
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Boston Children's Hospital
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
Feltham, Rebecca; Jamal, Kunzah; Tenev, Tencho et al. (2018) Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential. Cell Rep 23:470-484
Fu, Tian-Min; Shen, Chen; Li, Qiubai et al. (2018) Mechanism of ubiquitin transfer promoted by TRAF6. Proc Natl Acad Sci U S A 115:1783-1788
Hauenstein, Arthur V; Xu, Guozhou; Kabaleeswaran, Venkataraman et al. (2017) Evidence for M1-Linked Polyubiquitin-Mediated Conformational Change in NEMO. J Mol Biol 429:3793-3800
Wang, Li; Qiao, Qi; Ferrao, Ryan et al. (2017) Crystal structure of human IRAK1. Proc Natl Acad Sci U S A 114:13507-13512
Kleino, Anni; Ramia, Nancy F; Bozkurt, Gunes et al. (2017) Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-?B Signaling. Immunity 47:635-647.e6
Fu, Tian-Min; Li, Yang; Lu, Alvin et al. (2016) Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex. Mol Cell 64:236-250
Fu, Qingshan; Fu, Tian-Min; Cruz, Anthony C et al. (2016) Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Mol Cell 61:602-613
Ru, Heng; Chambers, Melissa G; Fu, Tian-Min et al. (2015) Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell 163:1138-1152
Onizawa, Michio; Oshima, Shigeru; Schulze-Topphoff, Ulf et al. (2015) The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol 16:618-27
Hauenstein, Arthur V; Zhang, Liman; Wu, Hao (2015) The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines. Curr Opin Struct Biol 31:75-83

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