Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AR002594-38
Application #
2077605
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-09-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
38
Fiscal Year
1996
Total Cost
Indirect Cost
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
Sigurdsson, Einar M (2006) Immunotherapy for conformational diseases. Curr Pharm Des 12:2569-85
Goni, Fernando; Sigurdsson, Einar M (2005) New directions towards safer and effective vaccines for Alzheimer's disease. Curr Opin Mol Ther 7:17-23
Goni, F; Knudsen, E; Schreiber, F et al. (2005) Mucosal vaccination delays or prevents prion infection via an oral route. Neuroscience 133:413-21
Sigurdsson, Einar M; Knudsen, Elin; Asuni, Ayodeji et al. (2004) An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives. J Neurosci 24:6277-82
Berasain, Patricia; Carmona, Carlos; Frangione, Blas et al. (2003) Specific cleavage sites on human IgG subclasses by cruzipain, the major cysteine proteinase from Trypanosoma cruzi. Mol Biochem Parasitol 130:23-9
Sigurdsson, Einar M; Brown, David R; Alim, Muhammad A et al. (2003) Copper chelation delays the onset of prion disease. J Biol Chem 278:46199-202
Sigurdsson, Einar M; Brown, David R; Daniels, Maki et al. (2002) Immunization delays the onset of prion disease in mice. Am J Pathol 161:13-7
Sigurdsson, E M; Scholtzova, H; Mehta, P D et al. (2001) Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am J Pathol 159:439-47
Aucouturier, P; Geissmann, F; Damotte, D et al. (2001) Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie. J Clin Invest 108:703-8
Vidal, R; Calero, M; Revesz, T et al. (2001) Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family. Gene 266:95-102

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