Matrix Metalloproteinases in Normal & Abnormal Skin

Eisen, Arthur Z.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37AR012129-29
• Application #: 2078290
• Study Section: Special Emphasis Panel (NSS)
• Project Start: 1978-04-01
• Project End: 1998-03-31
• Budget Start: 1996-04-01
• Budget End: 1997-03-31
• Support Year: 29
• Fiscal Year: 1996

Institution

• Name: Washington University
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 062761671
• City: Saint Louis
• State: MO
• Country: United States
• Zip Code: 63130

Publications

Karelina, T V; Bannikov, G A; Eisen, A Z (2000) Basement membrane zone remodeling during appendageal development in human fetal skin. The absence of type VII collagen is associated with gelatinase-A (MMP2) activity. J Invest Dermatol 114:371-5

Karelina, T V; Eisen, A Z (1998) Interstitial collagenase and the ED-B oncofetal domain of fibronectin are markers of angiogenesis in human skin tumors. Cancer Detect Prev 22:438-44

Li, L; Eisen, A Z; Sturman, E et al. (1998) Protein tyrosine phosphorylation in signalling pathways leading to the activation of gelatinase A: activation of gelatinase A by treatment with the protein tyrosine phosphatase inhibitor sodium orthovanadate. Biochim Biophys Acta 1405:110-20

Li, L; Akers, K; Eisen, A Z et al. (1997) Activation of gelatinase A (72-kDa type IV collagenase) induced by monensin in normal human fibroblasts. Exp Cell Res 232:322-30

Lee, A Y; Akers, K T; Collier, M et al. (1997) Intracellular activation of gelatinase A (72-kDa type IV collagenase) by normal fibroblasts. Proc Natl Acad Sci U S A 94:4424-9

Xia, T; Akers, K; Eisen, A Z et al. (1996) Comparison of cleavage site specificity of gelatinases A and B using collagenous peptides. Biochim Biophys Acta 1293:259-66

Karelina, T V; Goldberg, G I; Eisen, A Z (1995) Matrix metalloproteinases in blood vessel development in human fetal skin and in cutaneous tumors. J Invest Dermatol 105:411-7

Takagi, M; Konttinen, Y T; Santavirta, S et al. (1994) Extracellular matrix metalloproteinases around loose total hip prostheses. Acta Orthop Scand 65:281-6

Karelina, T V; Goldberg, G I; Eisen, A Z (1994) Matrilysin (PUMP) correlates with dermal invasion during appendageal development and cutaneous neoplasia. J Invest Dermatol 103:482-7

Seltzer, J L; Lee, A Y; Akers, K T et al. (1994) Activation of 72-kDa type IV collagenase/gelatinase by normal fibroblasts in collagen lattices is mediated by integrin receptors but is not related to lattice contraction. Exp Cell Res 213:365-74