Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AR032805-14
Application #
2078877
Study Section
Special Emphasis Panel (NSS)
Project Start
1983-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Physiology
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Geng, Yanyan; Magleby, Karl L (2015) Modal gating of endplate acetylcholine receptors: A proposed mechanism. J Gen Physiol 146:435-9
Geng, Yanyan; Wang, Xiaoyu; Magleby, Karl L (2013) Lack of negative slope in I-V plots for BK channels at positive potentials in the absence of intracellular blockers. J Gen Physiol 141:493-7
Landowne, David; Yuan, Bin; Magleby, Karl L (2013) Exponential sum-fitting of dwell-time distributions without specifying starting parameters. Biophys J 104:2383-91
Budelli, Gonzalo; Geng, Yanyan; Butler, Alice et al. (2013) Properties of Slo1 K+ channels with and without the gating ring. Proc Natl Acad Sci U S A 110:16657-62
Fernandez, Jose A; Skryma, Roman; Bidaux, Gabriel et al. (2012) Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors. J Biol Chem 287:2963-70
Manzanares, Dahis; Gonzalez, Carlos; Ivonnet, Pedro et al. (2011) Functional apical large conductance, Ca2+-activated, and voltage-dependent K+ channels are required for maintenance of airway surface liquid volume. J Biol Chem 286:19830-9
Chen, Ren-Shiang; Geng, Yanyan; Magleby, Karl L (2011) Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevated. J Gen Physiol 138:593-607
Fernandez, Jose A; Skryma, Roman; Bidaux, Gabriel et al. (2011) Voltage- and cold-dependent gating of single TRPM8 ion channels. J Gen Physiol 137:173-95
Shelley, Christopher; Niu, Xiaowei; Geng, Yanyan et al. (2010) Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+. J Gen Physiol 135:461-80
Shelley, Christopher; Magleby, Karl L (2008) Linking exponential components to kinetic states in Markov models for single-channel gating. J Gen Physiol 132:295-312

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