Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA016954-19
Application #
3481761
Study Section
Special Emphasis Panel (NSS)
Project Start
1981-09-01
Project End
1994-08-31
Budget Start
1994-03-01
Budget End
1994-08-31
Support Year
19
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
D'Agostino, Jaime; Zhang, Haoming; Kenaan, Cesar et al. (2015) Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Chlorpyrifos. Chem Res Toxicol 28:1484-95
Calinski, Diane M; Zhang, Haoming; Ludeman, Susan et al. (2015) Hydroxylation and N-dechloroethylation of Ifosfamide and deuterated Ifosfamide by the human cytochrome p450s and their commonly occurring polymorphisms. Drug Metab Dispos 43:1084-90
Zhang, Haoming; Lauver, D Adam; Lucchesi, Benedict R et al. (2013) Formation, reactivity, and antiplatelet activity of mixed disulfide conjugates of clopidogrel. Mol Pharmacol 83:848-56
Zhang, Haoming; Gay, Sean C; Shah, Manish et al. (2013) Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis. Biochemistry 52:355-64
Sridar, Chitra; Hanna, Imad; Hollenberg, Paul F (2013) Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches. Xenobiotica 43:336-45
Yoshigae, Yasushi; Sridar, Chitra; Kent, Ute M et al. (2013) The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation. Drug Metab Dispos 41:858-69
Kenaan, Cesar; Shea, Erin V; Lin, Hsia-lien et al. (2013) Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism. Drug Metab Dispos 41:101-10
Yoshigae, Yasushi; Kent, Ute M; Hollenberg, Paul F (2013) Role of the highly conserved threonine in cytochrome P450 2E1: prevention of H2O2-induced inactivation during electron transfer. Biochemistry 52:4636-47
Amunugama, Hemali T; Zhang, Haoming; Hollenberg, Paul F (2012) Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme. Drug Metab Dispos 40:1765-70
Lin, Hsia-lien; Kenaan, Cesar; Zhang, Haoming et al. (2012) Reaction of human cytochrome P450 3A4 with peroxynitrite: nitrotyrosine formation on the proximal side impairs its interaction with NADPH-cytochrome P450 reductase. Chem Res Toxicol 25:2642-53

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