Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA020525-20
Application #
2086854
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-02-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Conacci-Sorrell, Maralice; Ngouenet, Celine; Anderson, Sarah et al. (2014) Stress-induced cleavage of Myc promotes cancer cell survival. Genes Dev 28:689-707
Conacci-Sorrell, Maralice; Eisenman, Robert N (2011) Post-translational control of Myc function during differentiation. Cell Cycle 10:604-10
Conacci-Sorrell, Maralice; Ngouenet, Celine; Eisenman, Robert N (2010) Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell 142:480-93
Zindy, Frederique; Knoepfler, Paul S; Xie, Suqing et al. (2006) N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development. Proc Natl Acad Sci U S A 103:11579-83
Knoepfler, Paul S; Zhang, Xiao-yong; Cheng, Pei Feng et al. (2006) Myc influences global chromatin structure. EMBO J 25:2723-34
Hatton, Beryl A; Knoepfler, Paul S; Kenney, Anna Marie et al. (2006) N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res 66:8655-61
Okubo, Tadashi; Knoepfler, Paul S; Eisenman, Robert N et al. (2005) Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. Development 132:1363-74
Toyo-oka, Kazuhito; Hirotsune, Shinji; Gambello, Michael J et al. (2004) Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome. Hum Mol Genet 13:1057-67
Grandori, Carla; Wu, Kou-Juey; Fernandez, Paula et al. (2003) Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev 17:1569-74
Hirst, S K; Grandori, C (2000) Differential activity of conditional MYC and its variant MYC-S in human mortal fibroblasts. Oncogene 19:5189-97

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