Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA022860-18
Application #
2087102
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-02-01
Project End
1997-05-31
Budget Start
1995-06-01
Budget End
1997-05-31
Support Year
18
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Kozin, S V; Shkarin, P; Gerweck, L E (2001) The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics. Cancer Res 61:4740-3
Gerweck, L E (1998) Tumor pH: implications for treatment and novel drug design. Semin Radiat Oncol 8:176-82
Kozin, S V; Gerweck, L E (1998) Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: role of the transmembrane pH gradient. Br J Cancer 77:1580-5
Zietman, A L; Nakfoor, B M; Prince, E A et al. (1997) The effect of androgen deprivation and radiation therapy on an androgen-sensitive murine tumor: an in vitro and in vivo study. Cancer J Sci Am 3:31-6
Leunig, M; Yuan, F; Gerweck, L E et al. (1997) Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice. Int J Microcirc Clin Exp 17:1-9
Gerweck, L E; Seetharaman, K (1996) Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res 56:1194-8
Gerweck, L E; Zaidi, S T (1996) The reproducibility and relationship between single and fractionated dose estimates of the surviving fraction at 2 Gy. Int J Radiat Oncol Biol Phys 35:81-7
Leunig, M; Yuan, F; Berk, D A et al. (1996) Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice. Acta Orthop Scand 67:383-8
Leunig, M; Yuan, F; Gerweck, L E et al. (1995) Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach. Res Exp Med (Berl) 195:275-88
Gerweck, L E; Hetzel, F W (1995) PO2 in irradiated versus nonirradiated tumors of mice breathing oxygen at normal and elevated pressure. Int J Radiat Oncol Biol Phys 32:695-701

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