Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA028000-16
Application #
2087674
Study Section
Special Emphasis Panel (NSS)
Project Start
1980-04-01
Project End
1997-02-28
Budget Start
1995-04-01
Budget End
1997-02-28
Support Year
16
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Pathology
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Malejka-Giganti, Danuta; Bennett, Kristen K; Culp, Sandra J et al. (2005) Suppression of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis by pre-initiation treatment of rats with beta-naphthoflavone coincides with decreased levels of the carcinogen-derived DNA adducts in the mammary gland. Cancer Detect Prev 29:338-47
Horn, Thomas L; Reichert, Mark A; Bliss, Robin L et al. (2002) Modulations of P450 mRNA in liver and mammary gland and P450 activities and metabolism of estrogen in liver by treatment of rats with indole-3-carbinol. Biochem Pharmacol 64:393-404
Ritter, Clare L; Culp, Sandra J; Freeman, James P et al. (2002) DNA adducts from nitroreduction of 2,7-dinitrofluorene, a mammary gland carcinogen, catalyzed by rat liver or mammary gland cytosol. Chem Res Toxicol 15:536-44
Ritter, C L; Prigge, W F; Reichert, M A et al. (2001) Oxidations of 17beta-estradiol and estrone and their interconversions catalyzed by liver, mammary gland and mammary tumor after acute and chronic treatment of rats with indole-3-carbinol or beta-naphthoflavone. Can J Physiol Pharmacol 79:519-32
Ritter, C L; Decker, R W; Malejka-Giganti, D (2000) Reductions of nitro and 9-Oxo groups of environmental nitrofluorenes by the rat mammary gland in vitro. Chem Res Toxicol 13:793-800
Malejka-Giganti, D; Niehans, G A; Reichert, M A et al. (2000) Post-initiation treatment of rats with indole-3-carbinol or beta-naphthoflavone does not suppress 7, 12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis. Cancer Lett 160:209-18
Brauze, D; Malejka-Giganti, D (2000) A novel 4 S [3H]beta-naphthoflavone-binding protein in liver cytosol of female Sprague-Dawley rats treated with aryl hydrocarbon receptor agonists. Biochem J 347 Pt 3:787-95
Malejka-Giganti, D; Niehans, G A; Reichert, M A et al. (1999) Potent carcinogenicity of 2,7-dinitrofluorene, an environmental pollutant, for the mammary gland of female Sprague-Dawley rats. Carcinogenesis 20:2017-23
Ritter, C L; Malejka-Giganti, D (1998) Nitroreduction of nitrated and C-9 oxidized fluorenes in vitro. Chem Res Toxicol 11:1361-7
Brauze, D; Crow, J S; Malejka-Giganti, D (1997) Modulation by beta-naphthoflavone of ovarian hormone dependent responses in rat uterus and liver in vivo. Can J Physiol Pharmacol 75:1022-9

Showing the most recent 10 out of 29 publications