Humoral Regulation of Normal and Malignant Hempoiesis

Golde, David W.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 7R37CA030388-12
• Application #: 3482186
• Study Section: Special Emphasis Panel (NSS)
• Project Start: 1981-07-01
• Project End: 1993-12-31
• Budget Start: 1991-11-01
• Budget End: 1991-12-31
• Support Year: 12
• Fiscal Year: 1991

Institution

• Name: Sloan-Kettering Institute for Cancer Research
• DUNS #: 064931884
• City: New York
• State: NY
• Country: United States
• Zip Code: 10065

Publications

Dhar-Mascareno, Manya; Mascareno, Eduardo; Golde, David W (2009) Early signaling by vascular endothelial growth factor and placental growth factor in human bone marrow-derived endothelial cells is mediated by superoxide. J Vasc Res 46:601-8

Heaney, Mark L; Gardner, Jeffrey R; Karasavvas, Nicos et al. (2008) Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs. Cancer Res 68:8031-8

Perez-Cruz, Isabel; Carcamo, Juan M; Golde, David W (2007) Caspase-8 dependent TRAIL-induced apoptosis in cancer cell lines is inhibited by vitamin C and catalase. Apoptosis 12:225-34

K C, Sagun; Carcamo, Juan M; Golde, David W (2006) Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-MYC. Mutat Res 593:64-79

Chen, Jian; Carcamo, Juan M; Golde, David W (2006) The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling. J Biol Chem 281:22421-6

Dhar-Mascareno, Manya; Pedraza, Alicia; Golde, David W (2005) PI3-kinase activation by GM-CSF in endothelium is upstream of Jak/Stat pathway: role of alphaGMR. Biochem Biophys Res Commun 337:551-6

KC, Sagan; Carcamo, Juan M; Golde, David W (2005) Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury. FASEB J 19:1657-67

Dhar-Mascareno, Manya; Carcamo, Juan M; Golde, David W (2005) Hypoxia-reoxygenation-induced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin C. Free Radic Biol Med 38:1311-22

DeYulia Jr, Garrett J; Carcamo, Juan M; Borquez-Ojeda, Oriana et al. (2005) Hydrogen peroxide generated extracellularly by receptor-ligand interaction facilitates cell signaling. Proc Natl Acad Sci U S A 102:5044-9

Araten, David J; Golde, David W; Zhang, Rong H et al. (2005) A quantitative measurement of the human somatic mutation rate. Cancer Res 65:8111-7