Abstract

The response to irradiation of several different slowly-responding tissues will be studied with particular reference to the effect of dose fractionation but also as they relate to other insults, particularly surgery or an inflammatory response mimicking that after surgery. The tissues (and effects of interest) include the peritoneum (adhesion formation), dermal fibrovasculature (wound healing), liver (hepatocyte survival) and lung (pneumonitis). The animals used will be specific pathogen free mice. In parallel with quantitation of the dose fractionation response and of the time course of the various tissue effects, an effort will be made to elucidate the mechanisms underlying the responses. The purpose of the experiments is to understanding the biology of normal tissue responses to irradiation and to use that knowledge to improve both radiotherapy and multidisciplinary approaches in cancer treatment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA031612-12
Application #
3482224
Study Section
Special Emphasis Panel (NSS)
Project Start
1982-02-01
Project End
1995-01-31
Budget Start
1993-02-01
Budget End
1994-01-31
Support Year
12
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Withers, H R (2000) Biological aspects of conformal therapy. Acta Oncol 39:569-77
McBride, W H; Vegesna, V (2000) The role of T-cells in radiation pneumonitis after bone marrow transplantation. Int J Radiat Biol 76:517-21
Suwinski, R; Taylor, J M; Withers, H R (1999) The effect of heterogeneity in tumor cell kinetics on radiation dose-response. An exploratory investigation of a plateau effect. Radiother Oncol 50:57-66
Withers, H R (1999) Radiation biology and treatment options in radiation oncology. Cancer Res 59:1676s-1684s
Withers, H R; Suwinski, R (1998) Radiation dose response for subclinical metastases. Semin Radiat Oncol 8:224-8
Taylor, J M; Mason, K A; Vegesna, V et al. (1998) A non-parametric method of reconstructing single-dose survival curves from multi-fraction experiments. Int J Radiat Biol 74:583-93
McBride, W H; Vegesna, V (1997) Role of the thymus in radiation-induced lung damage after bone marrow transplantation. Radiat Res 147:501-5
Hong, J H; Chiang, C S; Sun, J R et al. (1997) Induction of c-fos and junB mRNA following in vivo brain irradiation. Brain Res Mol Brain Res 48:223-8
Vegesna, V; McBride, W H; Taylor, J M et al. (1997) Effect of low-dose radiation on mouse dermal tissue using wound strength as an endpoint. Int J Radiat Biol 72:645-52
Chiang, C S; Hong, J H; Stalder, A et al. (1997) Delayed molecular responses to brain irradiation. Int J Radiat Biol 72:45-53

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