Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA032613-14
Application #
2088361
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1983-07-01
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Petak, I; Tillman, D M; Harwood, F G et al. (2000) Fas-dependent and -independent mechanisms of cell death following DNA damage in human colon carcinoma cells. Cancer Res 60:2643-50
Harwood, F G; Kasibhatla, S; Petak, I et al. (2000) Regulation of FasL by NF-kappaB and AP-1 in Fas-dependent thymineless death of human colon carcinoma cells. J Biol Chem 275:10023-9
Tillman, D M; Petak, I; Houghton, J A (1999) A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells. Clin Cancer Res 5:425-30
Houghton, J A; Ebanks, R; Harwood, F G et al. (1998) Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells. Clin Cancer Res 4:2841-8
Tillman, D M; Harwood, F G; Gibson, A A et al. (1998) Expression of genes that regulate Fas signalling and Fas-mediated apoptosis in colon carcinoma cells. Cell Death Differ 5:450-7
Houghton, J A; Harwood, F G; Tillman, D M (1997) Thymineless death in colon carcinoma cells is mediated via fas signaling. Proc Natl Acad Sci U S A 94:8144-9
Houghton, J A; Harwood, F G; Gibson, A A et al. (1997) The fas signaling pathway is functional in colon carcinoma cells and induces apoptosis. Clin Cancer Res 3:2205-9
Harwood, F G; Frazier, M W; Krajewski, S et al. (1996) Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells. Oncogene 12:2057-67
Houghton, J A; Houghton, P J (1996) Cellular responses to antimetabolite anticancer agents: cytostasis versus cytotoxicity. Prog Cell Cycle Res 2:175-85
Houghton, J A; Tillman, D M; Harwood, F G (1995) Ratio of 2'-deoxyadenosine-5'-triphosphate/thymidine-5'-triphosphate influences the commitment of human colon carcinoma cells to thymineless death. Clin Cancer Res 1:723-30