Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA034570-14
Application #
2088706
Study Section
Special Emphasis Panel (NSS)
Project Start
1983-04-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Schwartz, Jeffrey L; Tamura, Yasuko; Jordan, Robert et al. (2004) Effect of p53 activation on cell growth, thymidine kinase-1 activity, and 3'-deoxy-3'fluorothymidine uptake. Nucl Med Biol 31:419-23
Grierson, John R; Schwartz, Jeffery L; Muzi, Mark et al. (2004) Metabolism of 3'-deoxy-3'-[F-18]fluorothymidine in proliferating A549 cells: validations for positron emission tomography. Nucl Med Biol 31:829-37
Rajendran, J G; Wilson, D C; Conrad, E U et al. (2003) [(18)F]FMISO and [(18)F]FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression. Eur J Nucl Med Mol Imaging 30:695-704
Schwartz, Jeffrey L; Tamura, Yasuko; Jordan, Robert et al. (2003) Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs. J Nucl Med 44:2027-32
Rasey, J S; Casciari, J J; Hofstrand, P D et al. (2000) Determining hypoxic fraction in a rat glioma by uptake of radiolabeled fluoromisonidazole. Radiat Res 153:84-92
Rasey, J S; Hofstrand, P D; Chin, L K et al. (1999) Characterization of [18F]fluoroetanidazole, a new radiopharmaceutical for detecting tumor hypoxia. J Nucl Med 40:1072-9
Schwartz, J L; Rasey, J; Wiens, L et al. (1999) Functional inactivation of p53 by HPV-E6 transformation is associated with a reduced expression of radiation-induced potentially lethal damage. Int J Radiat Biol 75:285-91
Maurer, B J; Ihnat, M A; Morgan, C et al. (1999) Growth of human tumor cells in macroporous microcarriers results in p53-independent, decreased cisplatin sensitivity relative to monolayers. Mol Pharmacol 55:938-47
Tewson, T J (1997) Synthesis of [18F]fluoroetanidazole: a potential new tracer for imaging hypoxia. Nucl Med Biol 24:755-60
Rasey, J S; Cornwell, M M; Maurer, B J et al. (1996) Growth and radiation response of cells grown in macroporous gelatin microcarriers (CultiSpher-G). Br J Cancer Suppl 27:S78-81

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