Ionic Regulation and Tumor Promotion

O'Brien, Thomas G.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37CA036353-07
• Application #: 3482338
• Study Section: Chemical Pathology Study Section (CPA)
• Project Start: 1984-02-01
• Project End: 1990-07-03
• Budget Start: 1990-02-01
• Budget End: 1990-07-03
• Support Year: 7
• Fiscal Year: 1990

Institution

• Name: Wistar Institute
• DUNS #: 042250712
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19104

Publications

Rosson, D; O'Brien, T G (1998) AP-1 activity affects the levels of induced erythroid and megakaryocytic differentiation of K562 cells. Arch Biochem Biophys 352:298-305

Civan, M M; Peterson-Yantorno, K; Sanchez-Torres, J et al. (1997) Potential contribution of epithelial Na+ channel to net secretion of aqueous humor. J Exp Zool 279:498-503

Rosson, D; O'Brien, T G; Kampherstein, J A et al. (1997) Protein kinase C-alpha activity modulates transepithelial permeability and cell junctions in the LLC-PK1 epithelial cell line. J Biol Chem 272:14950-3

Chalfant, M L; Civan, J M; Peterson-Yantorno, K et al. (1996) Regulation of epithelial Na+ permeability by protein kinase C is tissue specific. J Membr Biol 152:207-15

Guo, Y; O'Brien, T G (1996) Restoration of responsiveness to phorbol ester by reconstitution of a functional Na/K/Cl cotransporter in cotransporter-deficient BALB/c 3T3 cells. Mol Carcinog 17:35-40

Chalfant, M L; Peterson-Yantorno, K; O'Brien, T G et al. (1996) Regulation of epithelial Na+ channels from M-1 cortical collecting duct cells. Am J Physiol 271:F861-70

Mullin, J M; Soler, A P; Laughlin, K V et al. (1996) Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization. Exp Cell Res 227:12-22

Chalfant, M L; O'Brien, T G; Civan, M M (1996) Whole cell and unitary amiloride-sensitive sodium currents in M-1 mouse cortical collecting duct cells. Am J Physiol 270:C998-1010

Rosson, D; O'Brien, T G (1995) Constitutive c-myb expression in K562 cells inhibits induced erythroid differentiation but not tetradecanoyl phorbol acetate-induced megakaryocytic differentiation. Mol Cell Biol 15:772-9

Bourguignon, L Y; Jin, H (1995) Identification of the ankyrin-binding domain of the mouse T-lymphoma cell inositol 1,4,5-trisphosphate (IP3) receptor and its role in the regulation of IP3-mediated internal Ca2+ release. J Biol Chem 270:7257-60