Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA037037-11
Application #
2089217
Study Section
Special Emphasis Panel (NSS)
Project Start
1988-02-01
Project End
1997-01-31
Budget Start
1994-02-01
Budget End
1997-01-31
Support Year
11
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Rutgers University
Department
Biology
Type
Schools of Pharmacy
DUNS #
038633251
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901

  Publications

Smith, T J; Liao, A; Wang, L D et al. (1998) Characterization of xenobiotic-metabolizing enzymes and nitrosamine metabolism in the human esophagus. Carcinogenesis 19:667-72
Smith, T J; Guo, Z; Guengerich, F P et al. (1996) Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate. Carcinogenesis 17:809-13
Ardies, C M; Smith, T J; Kim, S et al. (1996) Induction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) activation in rat lung microsomes by chronic ethanol consumption and repeated running exercise. Cancer Lett 103:209-18
Wang, L D; Zhou, Q; Hong, J Y et al. (1996) p53 protein accumulation and gene mutations in multifocal esophageal precancerous lesions from symptom free subjects in a high incidence area for esophageal carcinoma in Henan, China. Cancer 77:1244-9
Smith, T J; Hong, J Y; Wang, Z Y et al. (1995) How can carcinogenesis be inhibited? Ann N Y Acad Sci 768:82-90
Smith, T J; Stoner, G D; Yang, C S (1995) Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides. Cancer Res 55:5566-73
Yang, C S; Smith, T J; Hong, J Y (1994) Cytochrome P-450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity: opportunities and limitations. Cancer Res 54:1982s-1986s
Wang, L D; Shi, S T; Zhou, Q et al. (1994) Changes in p53 and cyclin D1 protein levels and cell proliferation in different stages of human esophageal and gastric-cardia carcinogenesis. Int J Cancer 59:514-9
Gao, H; Wang, L D; Zhou, Q et al. (1994) p53 tumor suppressor gene mutation in early esophageal precancerous lesions and carcinoma among high-risk populations in Henan, China. Cancer Res 54:4342-6
Wang, L D; Hong, J Y; Qiu, S L et al. (1993) Accumulation of p53 protein in human esophageal precancerous lesions: a possible early biomarker for carcinogenesis. Cancer Res 53:1783-7

Showing the most recent 10 out of 60 publications