Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA039076-13
Application #
2089727
Study Section
Special Emphasis Panel (NSS)
Project Start
1984-06-01
Project End
1997-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Kumar, N Vinay; Eblen, Scott T; Weber, Michael J (2004) Identifying specific kinase substrates through engineered kinases and ATP analogs. Methods 32:389-97
Eblen, Scott T; Slack-Davis, Jill K; Tarcsafalvi, Adel et al. (2004) Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion. Mol Cell Biol 24:2308-17
Vomastek, Tomas; Schaeffer, Hans-Joerg; Tarcsafalvi, Adel et al. (2004) Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. Proc Natl Acad Sci U S A 101:6981-6
Eblen, Scott T; Kumar, N Vinay; Shah, Kavita et al. (2003) Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J Biol Chem 278:14926-35
Bakin, Robert E; Gioeli, Daniel; Bissonette, Eric A et al. (2003) Attenuation of Ras signaling restores androgen sensitivity to hormone-refractory C4-2 prostate cancer cells. Cancer Res 63:1975-80
Eblen, Scott T; Slack, Jill K; Weber, Michael J et al. (2002) Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol Cell Biol 22:6023-33
Carson, Jonathan P; Behnam, Marcelina; Sutton, Jennifer N et al. (2002) Smac is required for cytochrome c-induced apoptosis in prostate cancer LNCaP cells. Cancer Res 62:18-23
Gioeli, Daniel; Ficarro, Scott B; Kwiek, Jesse J et al. (2002) Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J Biol Chem 277:29304-14
Kulik, G; Carson, J P; Vomastek, T et al. (2001) Tumor necrosis factor alpha induces BID cleavage and bypasses antiapoptotic signals in prostate cancer LNCaP cells. Cancer Res 61:2713-9
Gioeli, D; Zecevic, M; Weber, M J (2001) Immunostaining for activated extracellular signal-regulated kinases in cells and tissues. Methods Enzymol 332:343-53

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