As a result of their clonal origin, lymphoid tumors present as tumor-specific antigens unique cell surface epitopes related their recognition structures. We have produced lymphoma-specific monoclonal antibodies and demonstrated that the target structure, a disulfide-bonded heterodimer, is the T cell antigen specific receptor. Nearest-neighbor analysis of the receptor using chemical cross-linkers demonstrated that the receptor is part of a multichain complex. Recently, we have identified another heterodimer on the surface of T lymphoma cells. This molecule is serologically distinct from the alpha/beta antigen receptor and may represent a new family of T cell specific cell surface molecule. Our current goals are (1) to use conventional methods and recombinant DNA technology to produce additional antibodies to the components of the T cell receptor complex, (2) to evaluate their efficacy in specific immunotherapy, and (3) to further characterize the novel T cell heterodimer and determine its relationship to the T cell antigen receptor.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37CA040041-08
Application #
3482455
Study Section
Special Emphasis Panel (NSS)
Project Start
1985-01-01
Project End
1994-03-31
Budget Start
1991-04-01
Budget End
1992-03-31
Support Year
8
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704
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