Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37CA040530-04
Application #
3482477
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1984-12-01
Project End
1992-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Diasio, R B; Lu, Z; Zhang, R et al. (1995) Fluoropyrimidine catabolism. Cancer Treat Res 78:71-93
Diasio, R B; Van Kuilenburg, A B; Lu, Z et al. (1994) Determination of dihydropyrimidine dehydrogenase (DPD) in fibroblasts of a DPD deficient pediatric patient and family members using a polyclonal antibody to human DPD. Adv Exp Med Biol 370:7-10
Kwakye, J B; Barnes, S; Diasio, R B (1993) Identification of bile acid coenzyme A synthetase in rat kidney. J Lipid Res 34:95-9
Zhang, R; Lu, Z; Liu, T et al. (1993) Circadian rhythm of rat spleen cytoplasmic thymidine kinase. Biochem Pharmacol 45:1115-9
Zhang, R; Lu, Z; Liu, T et al. (1993) Relationship between circadian-dependent toxicity of 5-fluorodeoxyuridine and circadian rhythms of pyrimidine enzymes: possible relevance to fluoropyrimidine chemotherapy. Cancer Res 53:2816-22
Zhang, R W; Soong, S J; Liu, T P et al. (1992) Pharmacokinetics and tissue distribution of 2-fluoro-beta-alanine in rats. Potential relevance to toxicity pattern of 5-fluorouracil. Drug Metab Dispos 20:113-9
Zhang, R; Barnes, S; Diasio, R B (1992) Differential intestinal deconjugation of taurine and glycine bile acid N-acyl amidates in rats. Am J Physiol 262:G351-8
Lu, Z H; Zhang, R; Diasio, R B (1992) Purification and characterization of dihydropyrimidine dehydrogenase from human liver. J Biol Chem 267:17102-9
Zhang, R W; Barnes, S; Diasio, R B (1991) Disposition and metabolism of 2-fluoro-beta-alanine conjugates of bile acids following secretion into bile. Biochim Biophys Acta 1096:179-86
Daher, G C; Harris, B E; Willard, E M et al. (1991) Biochemical basis for circadian-dependent metabolism of fluoropyrimidines. Ann N Y Acad Sci 618:350-61

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