Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA044982-10
Application #
2091687
Study Section
Special Emphasis Panel (NSS)
Project Start
1986-09-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Ayene, Iraimoudi S; Biaglow, John E; Kachur, Alexander V et al. (2008) Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication. J Cell Biochem 103:123-35
Tuttle, Stephen W; Maity, Amit; Oprysko, Patricia R et al. (2007) Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia. J Biol Chem 282:36790-6
Biaglow, John E; Ayene, Iraimoudi S; Tuttle, Stephen W et al. (2006) Role of vicinal protein thiols in radiation and cytotoxic responses. Radiat Res 165:307-17
Biaglow, John E; Lee, Intae; Donahue, Jerry et al. (2003) Glutathione depletion or radiation treatment alters respiration and induces apoptosis in R3230Ac mammary carcinoma. Adv Exp Med Biol 530:153-64
Biaglow, John E; Ayene, Iraimoudi S; Koch, Cameron J et al. (2003) Radiation response of cells during altered protein thiol redox. Radiat Res 159:484-94
Ayene, Iraimoudi S; Stamato, Thomas D; Mauldin, Stanley K et al. (2002) Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress. J Biol Chem 277:9929-35
Tuttle, S; Stamato, T; Perez, M L et al. (2000) Glucose-6-phosphate dehydrogenase and the oxidative pentose phosphate cycle protect cells against apoptosis induced by low doses of ionizing radiation. Radiat Res 153:781-7
Biaglow, J E; Donahue, J; Tuttle, S et al. (2000) A method for measuring disulfide reduction by cultured mammalian cells: relative contributions of glutathione-dependent and glutathione-independent mechanisms. Anal Biochem 281:77-86
Biaglow, J E; Ayene, I S; Koch, C J et al. (2000) G6PD deficient cells and the bioreduction of disulfides: effects of DHEA, GSH depletion and phenylarsine oxide. Biochem Biophys Res Commun 273:846-52
Tartier, L; McCarey, Y L; Biaglow, J E et al. (2000) Apoptosis induced by dithiothreitol in HL-60 cells shows early activation of caspase 3 and is independent of mitochondria. Cell Death Differ 7:1002-10

Showing the most recent 10 out of 42 publications