Abstract

The a6|34 integrin binds to the basal lamina component laminin-5. Integrin

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA058976-18
Application #
7777859
Study Section
Special Emphasis Panel (NSS)
Program Officer
Snyderwine, Elizabeth G
Project Start
1994-01-01
Project End
2012-02-28
Budget Start
2010-03-01
Budget End
2012-02-28
Support Year
18
Fiscal Year
2010
Total Cost
$410,916
Indirect Cost

  Institution

Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Fan, Jie; Cai, Bin; Zeng, Min et al. (2011) Integrin ?4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF. Ann Biomed Eng 39:2223-2241
Pylayeva, Yuliya; Gillen, Kelly M; Gerald, William et al. (2009) Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest 119:252-66
Oktay, Kutluk; Buyuk, Erkan; Oktem, Ozgur et al. (2008) The c-Jun N-terminal kinase JNK functions upstream of Aurora B to promote entry into mitosis. Cell Cycle 7:533-41
Pylayeva, Yuliya; Guo, Wenjun; Giancotti, Filippo G (2007) Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progression. Methods Enzymol 426:439-61
Guo, Wenjun; Pylayeva, Yuliya; Pepe, Angela et al. (2006) Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126:489-502
Nikolopoulos, Sotiris N; Blaikie, Pamela; Yoshioka, Toshiaki et al. (2005) Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol Cell Biol 25:6090-102
Nikolopoulos, Sotiris N; Blaikie, Pamela; Yoshioka, Toshiaki et al. (2004) Integrin beta4 signaling promotes tumor angiogenesis. Cancer Cell 6:471-83
Gagnoux-Palacios, Laurent; Dans, Michael; van't Hof, Wouter et al. (2003) Compartmentalization of integrin alpha6beta4 signaling in lipid rafts. J Cell Biol 162:1189-96
Wary, K K; Mariotti, A; Zurzolo, C et al. (1998) A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 94:625-34
Mainiero, F; Murgia, C; Wary, K K et al. (1997) The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J 16:2365-75

Showing the most recent 10 out of 12 publications