Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DA003102-08
Application #
3482664
Study Section
Pharmacology I Research Subcommittee (DABR)
Project Start
1982-09-30
Project End
1993-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
8
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Henry M. Jackson Fdn for the Adv Mil/Med
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20852
Gouty, S; Brown, J M; Rosenberger, J et al. (2010) MPTP treatment increases expression of pre-pro-nociceptin/orphanin FQ mRNA in a subset of substantia nigra reticulata neurons. Neuroscience 169:269-78
Di Benedetto, Manuela; Cavina, Chiara; D'Addario, Claudio et al. (2009) Alterations of N/OFQ and NOP receptor gene expression in the substantia nigra and caudate putamen of MPP+ and 6-OHDA lesioned rats. Neuropharmacology 56:761-7
Brown, Jeffrey M; Gouty, Shawn; Iyer, Varsha et al. (2006) Differential protection against MPTP or methamphetamine toxicity in dopamine neurons by deletion of ppN/OFQ expression. J Neurochem 98:495-505
Marti, Matteo; Mela, Flora; Fantin, Martina et al. (2005) Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease. J Neurosci 25:9591-601
Buzas, Beata; Rosenberger, J; Kim, Kee-Won et al. (2002) Inflammatory mediators increase the expression of nociceptin/orphanin FQ in rat astrocytes in culture. Glia 39:237-46
Buzas, B; Symes, A J; Cox, B M (1999) Regulation of nociceptin/orphanin FQ gene expression by neuropoietic cytokines and neurotrophic factors in neurons and astrocytes. J Neurochem 72:1882-9
Azaryan, A V; Clock, B J; Rosenberger, J G et al. (1998) Transient upregulation of mu opioid receptor mRNA levels in nucleus accumbens during chronic cocaine administration. Can J Physiol Pharmacol 76:278-83
Buzas, B; Rosenberger, J; Cox, B M (1998) Activity and cyclic AMP-dependent regulation of nociceptin/orphanin FQ gene expression in primary neuronal and astrocyte cultures. J Neurochem 71:556-63
Buzas, B; Rosenberger, J; Cox, B M (1998) Ca2+/calmodulin-dependent transcriptional activation of delta-opioid receptor gene expression induced by membrane depolarization in NG108-15 cells. J Neurochem 70:105-12
Buzas, B; Cox, B M (1997) Quantitative analysis of mu and delta opioid receptor gene expression in rat brain and peripheral ganglia using competitive polymerase chain reaction. Neuroscience 76:479-89

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