Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK013914-27
Application #
2136813
Study Section
Special Emphasis Panel (NSS)
Project Start
1974-11-01
Project End
1997-11-30
Budget Start
1996-02-27
Budget End
1996-11-30
Support Year
27
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Biochemistry
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Menting, John G; Yang, Yanwu; Chan, Shu Jin et al. (2014) Protective hinge in insulin opens to enable its receptor engagement. Proc Natl Acad Sci U S A 111:E3395-404
Menting, John G; Whittaker, Jonathan; Margetts, Mai B et al. (2013) How insulin engages its primary binding site on the insulin receptor. Nature 493:241-5
Steiner, Donald F (2011) On the discovery of precursor processing. Methods Mol Biol 768:3-11
Steiner, Donald F (2011) Adventures with insulin in the islets of Langerhans. J Biol Chem 286:17399-421
Smith, Brian J; Huang, Kun; Kong, Geoffrey et al. (2010) Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists. Proc Natl Acad Sci U S A 107:6771-6
Wardman, Jonathan H; Zhang, Xin; Gagnon, Sandra et al. (2010) Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics. J Neurochem 114:215-25
Stoy, Julie; Steiner, Donald F; Park, Soo-Young et al. (2010) Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene. Rev Endocr Metab Disord 11:205-15
Park, Soo-Young; Ye, Honggang; Steiner, Donald F et al. (2010) Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted. Biochem Biophys Res Commun 391:1449-54
Zhang, Xin; Pan, Hui; Peng, Bonnie et al. (2010) Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis. J Neurochem 112:1168-79
Steiner, D F; Park, S-Y; Stoy, J et al. (2009) A brief perspective on insulin production. Diabetes Obes Metab 11 Suppl 4:189-96

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