Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK015289-27
Application #
6523948
Study Section
Special Emphasis Panel (NSS)
Program Officer
May, Michael K
Project Start
1978-01-01
Project End
2004-06-30
Budget Start
2002-09-01
Budget End
2004-06-30
Support Year
27
Fiscal Year
2002
Total Cost
$204,380
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Hirschi, Alexander; Martin, William J; Luka, Zigmund et al. (2016) G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme. RNA 22:1250-60
Luka, Zigmund; Pakhomova, Svetlana; Loukachevitch, Lioudmila V et al. (2014) Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate. Biochem Biophys Res Commun 449:392-8
Luka, Zigmund; Pakhomova, Svetlana; Loukachevitch, Lioudmila V et al. (2014) Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate. Protein Sci 23:993-8
Carrasco, Manuel; Rabaneda, Luis G; Murillo-Carretero, Maribel et al. (2014) Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance. Hippocampus 24:840-52
Luka, Zigmund; Pakhomova, Svetlana; Loukachevitch, Lioudmila V et al. (2012) Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate. Biochim Biophys Acta 1824:286-91
Martínez-López, Nuria; García-Rodríguez, Juan L; Varela-Rey, Marta et al. (2012) Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1. Gastroenterology 143:787-798.e13
Luka, Zigmund; Moss, Frank; Loukachevitch, Lioudmila V et al. (2011) Histone demethylase LSD1 is a folate-binding protein. Biochemistry 50:4750-6
Vázquez-Chantada, Mercedes; Fernández-Ramos, David; Embade, Nieves et al. (2010) HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology 138:1943-53
Varela-Rey, Marta; Martínez-López, Nuria; Fernández-Ramos, David et al. (2010) Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide. Hepatology 52:105-14
Conde-Vancells, Javier; Rodriguez-Suarez, Eva; Gonzalez, Esperanza et al. (2010) Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples. Proteomics Clin Appl 4:416-25

Showing the most recent 10 out of 56 publications