Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK018573-35
Application #
2137208
Study Section
Special Emphasis Panel (NSS)
Project Start
1975-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
35
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Dobbins, Robert L; Malloy, Craig R (2003) Measuring in-vivo metabolism using nuclear magnetic resonance. Curr Opin Clin Nutr Metab Care 6:501-9
Brown, Nicholas F (2003) Expression, purification, and reconstitution of rat liver carnitine palmitoyltransferase I. Methods Mol Biol 228:281-301
Dobbins, Robert L; Szczepaniak, Lidia S; Zhang, Weiguo et al. (2003) Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion. Am J Physiol Endocrinol Metab 284:E778-87
Dobbins, Robert L; Szczepaniak, Lidia S; Myhill, Jeff et al. (2002) The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. Diabetes 51:1825-33
Dobbins, R L; Szczepaniak, L S; Bentley, B et al. (2001) Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. Diabetes 50:123-30
Caserta, F; Tchkonia, T; Civelek, V N et al. (2001) Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes. Am J Physiol Endocrinol Metab 280:E238-47
McGarry, J D (2001) Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between. Biochem Soc Trans 29:241-5
Mulder, H; Lu, D; Finley 4th, J et al. (2001) Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells. J Biol Chem 276:6479-84
Brown, N F; Mullur, R S; Subramanian, I et al. (2001) Molecular characterization of L-CPT I deficiency in six patients: insights into function of the native enzyme. J Lipid Res 42:1134-42
McGarry, J D; Brown, N F (2000) Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity. Biochem J 349:179-87

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