Experimental Diabetic Autonomic Neuropathy

Schmidt, Robert Edward

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37DK019645-25
• Application #: 6516991
• Study Section: Special Emphasis Panel (ZRG1-BDCN-2 (01))
• Program Officer: Jones, Teresa L Z
• Project Start: 1977-02-01
• Project End: 2004-06-30
• Budget Start: 2002-07-01
• Budget End: 2003-06-30
• Support Year: 25
• Fiscal Year: 2002
• Total Cost: $313,462

Institution

• Name: Washington University
• Department: Pathology
• Type: Schools of Medicine
• DUNS #: 062761671
• City: Saint Louis
• State: MO
• Country: United States
• Zip Code: 63130

Publications

Schmidt, Robert E; Feng, Dongyan; Wang, Qiuling et al. (2011) Effect of insulin and an erythropoietin-derived peptide (ARA290) on established neuritic dystrophy and neuronopathy in Akita (Ins2 Akita) diabetic mouse sympathetic ganglia. Exp Neurol 232:126-35

Beirowski, Bogdan; Gustin, Jason; Armour, Sean M et al. (2011) Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A 108:E952-61

Viader, Andreu; Golden, Judith P; Baloh, Robert H et al. (2011) Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J Neurosci 31:10128-40

Obrosova, Irina G; Stavniichuk, Roman; Drel, Viktor R et al. (2010) Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies. Am J Pathol 177:1436-47

Mancuso, David J; Kotzbauer, Paul; Wozniak, David F et al. (2009) Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction. J Biol Chem 284:35632-44

Schmidt, Robert E; Green, Karen G; Snipes, Lisa L et al. (2009) Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia. Exp Neurol 216:207-18

Schmidt, Robert E; Parvin, Curtis A; Green, Karen G (2008) Synaptic ultrastructural alterations anticipate the development of neuroaxonal dystrophy in sympathetic ganglia of aged and diabetic mice. J Neuropathol Exp Neurol 67:1166-86

McCandless, Erin E; Piccio, Laura; Woerner, B Mark et al. (2008) Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis. Am J Pathol 172:799-808

Schmidt, Robert E; Green, Karen G; Feng, Dongyan et al. (2008) Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice. Exp Neurol 209:161-70

Ryu, Elizabeth J; Wang, James Y T; Le, Nam et al. (2007) Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss. J Neurosci 27:11552-9