Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK019645-25
Application #
6516991
Study Section
Special Emphasis Panel (ZRG1-BDCN-2 (01))
Program Officer
Jones, Teresa L Z
Project Start
1977-02-01
Project End
2004-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
25
Fiscal Year
2002
Total Cost
$313,462
Indirect Cost
Name
Washington University
Department
Pathology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Schmidt, Robert E; Feng, Dongyan; Wang, Qiuling et al. (2011) Effect of insulin and an erythropoietin-derived peptide (ARA290) on established neuritic dystrophy and neuronopathy in Akita (Ins2 Akita) diabetic mouse sympathetic ganglia. Exp Neurol 232:126-35
Beirowski, Bogdan; Gustin, Jason; Armour, Sean M et al. (2011) Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A 108:E952-61
Viader, Andreu; Golden, Judith P; Baloh, Robert H et al. (2011) Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J Neurosci 31:10128-40
Obrosova, Irina G; Stavniichuk, Roman; Drel, Viktor R et al. (2010) Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies. Am J Pathol 177:1436-47
Mancuso, David J; Kotzbauer, Paul; Wozniak, David F et al. (2009) Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction. J Biol Chem 284:35632-44
Schmidt, Robert E; Green, Karen G; Snipes, Lisa L et al. (2009) Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia. Exp Neurol 216:207-18
Schmidt, Robert E; Parvin, Curtis A; Green, Karen G (2008) Synaptic ultrastructural alterations anticipate the development of neuroaxonal dystrophy in sympathetic ganglia of aged and diabetic mice. J Neuropathol Exp Neurol 67:1166-86
McCandless, Erin E; Piccio, Laura; Woerner, B Mark et al. (2008) Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis. Am J Pathol 172:799-808
Schmidt, Robert E; Green, Karen G; Feng, Dongyan et al. (2008) Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice. Exp Neurol 209:161-70
Ryu, Elizabeth J; Wang, James Y T; Le, Nam et al. (2007) Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss. J Neurosci 27:11552-9

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