Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37DK025306-12S1
Application #
3483447
Study Section
Metabolism Study Section (MET)
Project Start
1978-09-01
Project End
1991-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
12
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Tirabassi, Rebecca S; Guberski, Dennis L; Blankenhorn, Elizabeth P et al. (2010) Infection with viruses from several families triggers autoimmune diabetes in LEW*1WR1 rats: prevention of diabetes by maternal immunization. Diabetes 59:110-8
Jurczyk, Agata; Pino, Steven C; O'Sullivan-Murphy, Bryan et al. (2010) A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. PLoS One 5:e11812
Blankenhorn, Elizabeth P; Cort, Laura; Greiner, Dale L et al. (2009) Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex. Diabetes 58:2930-8
Mordes, John P; Cort, Laura; Norowski, Elaine et al. (2009) Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus. Mamm Genome 20:162-9
Chopra, Prerna; Diiorio, Philip; Pino, Steven C et al. (2009) Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat. In Vivo 23:195-201
Pino, Steven C; O'Sullivan-Murphy, Bryan; Lidstone, Erich A et al. (2009) CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. PLoS One 4:e5468
Pino, Steven C; O'Sullivan-Murphy, Bryan; Lidstone, Erich A et al. (2008) Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. Cell Stress Chaperones 13:421-34
Zipris, Danny; Lien, Egil; Nair, Anjali et al. (2007) TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J Immunol 178:693-701
Blankenhorn, Elizabeth P; Descipio, Cheryl; Rodemich, Lucy et al. (2007) Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene. Ann N Y Acad Sci 1103:128-31
Morrison, Alan R; Moss, Joel; Stevens, Linda A et al. (2006) ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose). J Biol Chem 281:33363-72

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