Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK025387-18
Application #
2137714
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1979-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Hegan, Peter S; Chandhoke, Surjit K; Barone, Christina et al. (2016) Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum. Cytoskeleton (Hoboken) 73:163-79
Hegan, Peter S; Ostertag, Eric; Geurts, Aron M et al. (2015) Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells. Cytoskeleton (Hoboken) 72:503-16
Hegan, Peter S; Kravtsov, Dmitri V; Caputo, Christina et al. (2015) Restoration of cytoskeletal and membrane tethering defects but not defects in membrane trafficking in the intestinal brush border of mice lacking both myosin Ia and myosin VI. Cytoskeleton (Hoboken) 72:455-76
Hegan, Peter S; Lanahan, Anthony A; Simons, Michael et al. (2015) Myosin VI and cardiomyopathy: Left ventricular hypertrophy, fibrosis, and both cardiac and pulmonary vascular endothelial cell defects in the Snell's waltzer mouse. Cytoskeleton (Hoboken) 72:373-87
Hegan, Peter S; Giral, Hector; Levi, Moshe et al. (2012) Myosin VI is required for maintenance of brush border structure, composition, and membrane trafficking functions in the intestinal epithelial cell. Cytoskeleton (Hoboken) 69:235-51
Mazzolini, Rocco; Dopeso, Higinio; Mateo-Lozano, Silvia et al. (2012) Brush border myosin Ia has tumor suppressor activity in the intestine. Proc Natl Acad Sci U S A 109:1530-5
Kravtsov, Dmitri V; Caputo, Christina; Collaco, Anne et al. (2012) Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Traffic 13:1072-82
Chandhoke, Surjit K; Mooseker, Mark S (2012) A role for myosin IXb, a motor-RhoGAP chimera, in epithelial wound healing and tight junction regulation. Mol Biol Cell 23:2468-80
Ramamurthy, Bhagavathi; Cao, Wenxiang; De la Cruz, Enrique M et al. (2012) Plus-end directed myosins accelerate actin filament sliding by single-headed myosin VI. Cytoskeleton (Hoboken) 69:59-69
Collaco, Anne; Jakab, Robert; Hegan, Peter et al. (2010) Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine. J Biol Chem 285:17177-87

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