Pathogenesis of Autoimmune Diabetes in Mice

Leiter, Edward H.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37DK027722-16
• Application #: 2138045
• Study Section: Pathology A Study Section (PTHA)
• Project Start: 1981-05-01
• Project End: 1999-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 16
• Fiscal Year: 1996

Institution

• Name: Jackson Laboratory
• DUNS #: 042140483
• City: Bar Harbor
• State: ME
• Country: United States
• Zip Code: 04609

Publications

Chen, Jing; Gusdon, Aaron M; Piganelli, Jon et al. (2011) mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic ?-cell. Diabetes 60:355-9

Chen, Yi-Guang; Scheuplein, Felix; Driver, John P et al. (2011) Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice. J Immunol 186:4278-84

Chen, Jing; Lu, Ying; Lee, Chul-Ho et al. (2008) Commonalities of genetic resistance to spontaneous autoimmune and free radical--mediated diabetes. Free Radic Biol Med 45:1263-70

Reifsnyder, Peter; Schott, William; Pomerleau, Darcy et al. (2008) Bone marrow expressing a diabetes resistance MHC class II allele: diabetes deviation by chronic immune stimulation. Novartis Found Symp 292:32-46;discussion 46-9, 122-9, 2

Chen, Jing; Chen, Yi-Guang; Reifsnyder, Peter C et al. (2006) Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. J Immunol 176:4590-9

Lee, Chul-Ho; Chen, Yi-Guang; Chen, Jing et al. (2006) Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis. Diabetes 55:171-8

Chen, Yi-Guang; Chen, Jing; Osborne, Melissa A et al. (2006) CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. J Immunol 177:2939-47

Leiter, Edward H; Lee, Chul-Ho (2005) Mouse models and the genetics of diabetes: is there evidence for genetic overlap between type 1 and type 2 diabetes? Diabetes 54 Suppl 2:S151-8

Mathews, C E; Leiter, E H; Spirina, O et al. (2005) mt-Nd2 Allele of the ALR/Lt mouse confers resistance against both chemically induced and autoimmune diabetes. Diabetologia 48:261-7

Lee, Chul-Ho; Reifsnyder, Peter C; Naggert, Jurgen K et al. (2005) Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis. Diabetes 54:2525-32