Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK030457-15
Application #
2138388
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1982-01-01
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Thomas, M K; Devon, O N; Lee, J H et al. (2001) Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1. J Clin Invest 108:319-29
Thomas, M K; Lee, J H; Rastalsky, N et al. (2001) Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells. Endocrinology 142:1033-40
Zulewski, H; Abraham, E J; Gerlach, M J et al. (2001) Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50:521-33
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Thomas, M K; Rastalsky, N; Lee, J H et al. (2000) Hedgehog signaling regulation of insulin production by pancreatic beta-cells. Diabetes 49:2039-47
Clocquet, A R; Egan, J M; Stoffers, D A et al. (2000) Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene). Diabetes 49:1856-64
Hani, E H; Stoffers, D A; Chevre, J C et al. (1999) Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest 104:R41-8
Ubeda, M; Vallejo, M; Habener, J F (1999) CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol Cell Biol 19:7589-99
Kieffer, T J; Habener, J F (1999) The glucagon-like peptides. Endocr Rev 20:876-913
Seufert, J; Kieffer, T J; Habener, J F (1999) Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Proc Natl Acad Sci U S A 96:674-9

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