Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK031396-14
Application #
2138615
Study Section
Special Emphasis Panel (NSS)
Project Start
1982-07-01
Project End
1996-11-30
Budget Start
1996-03-25
Budget End
1996-11-30
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Perides, George; Weiss, Eric R; Michael, Emily S et al. (2011) TNF-alpha-dependent regulation of acute pancreatitis severity by Ly-6C(hi) monocytes in mice. J Biol Chem 286:13327-35
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Laukkarinen, Johanna M; Van Acker, Gijs J D; Weiss, Eric R et al. (2007) A mouse model of acute biliary pancreatitis induced by retrograde pancreatic duct infusion of Na-taurocholate. Gut 56:1590-8
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Van Acker, Gijs J D; Perides, George; Weiss, Eric R et al. (2007) Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis. J Biol Chem 282:22140-9
Song, Albert M; Bhagat, Lakshmi; Singh, Vijay P et al. (2002) Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol 283:G1166-74
Frossard, J-L; Bhagat, L; Lee, H S et al. (2002) Both thermal and non-thermal stress protect against caerulein induced pancreatitis and prevent trypsinogen activation in the pancreas. Gut 50:78-83
Van Acker, Gijs J D; Saluja, Ashok K; Bhagat, Lakshmi et al. (2002) Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity. Am J Physiol Gastrointest Liver Physiol 283:G794-800
Bhagat, Lakshmi; Singh, Vijay P; Song, Albert M et al. (2002) Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats. Gastroenterology 122:156-65
Hietaranta, A J; Singh, V P; Bhagat, L et al. (2001) Water immersion stress prevents caerulein-induced pancreatic acinar cell nf-kappa b activation by attenuating caerulein-induced intracellular Ca2+ changes. J Biol Chem 276:18742-7

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