Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK033649-14
Application #
2139116
Study Section
Special Emphasis Panel (NSS)
Program Officer
Laughlin, Maren R
Project Start
1983-08-01
Project End
1998-03-31
Budget Start
1996-06-01
Budget End
1998-03-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Kruszynska, Yolanta T; Olefsky, Jerrold M; Frias, Juan P (2003) Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistance. Metabolism 52:233-8
Kruszynska, Yolanta T; Worrall, Dorothy Sears; Ofrecio, Jachelle et al. (2002) Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. J Clin Endocrinol Metab 87:226-34
Hevener, Andrea; Reichart, Donna; Janez, Andrej et al. (2002) Female rats do not exhibit free fatty acid-induced insulin resistance. Diabetes 51:1907-12
Frias, J P; Macaraeg, G B; Ofrecio, J et al. (2001) Decreased susceptibility to fatty acid-induced peripheral tissue insulin resistance in women. Diabetes 50:1344-50
Hevener, A L; Reichart, D; Janez, A et al. (2001) Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats. Diabetes 50:2316-22
Frias, J P; Yu, J G; Kruszynska, Y T et al. (2000) Metabolic effects of troglitazone therapy in type 2 diabetic, obese, and lean normal subjects. Diabetes Care 23:64-9
Frias, J P; Basabe, L; Macaraeg, G et al. (2000) Lack of effect of a physiological elevation of plasma non-esterified fatty acid levels on insulin secretion. Diabetes Metab 26:133-9
Kruszynska, Y T; Yu, J G; Olefsky, J M et al. (2000) Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects. Diabetes 49:633-9
Yu, J G; Kruszynska, Y T; Mulford, M I et al. (1999) A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients. Diabetes 48:2414-21
Kruszynska, Y T; Mukherjee, R; Jow, L et al. (1998) Skeletal muscle peroxisome proliferator- activated receptor-gamma expression in obesity and non- insulin-dependent diabetes mellitus. J Clin Invest 101:543-8

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