Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK034909-11
Application #
2139421
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1984-12-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Sun, Xun; Dyson, H Jane; Wright, Peter E (2018) Kinetic analysis of the multistep aggregation pathway of human transthyretin. Proc Natl Acad Sci U S A 115:E6201-E6208
Leach, Benjamin I; Zhang, Xin; Kelly, Jeffery W et al. (2018) NMR Measurements Reveal the Structural Basis of Transthyretin Destabilization by Pathogenic Mutations. Biochemistry 57:4421-4430
Sun, Xun; Dyson, H Jane; Wright, Peter E (2017) Fluorotryptophan Incorporation Modulates the Structure and Stability of Transthyretin in a Site-Specific Manner. Biochemistry 56:5570-5581
Lim, Kwang Hun; Dasari, Anvesh K R; Hung, Ivan et al. (2016) Solid-State NMR Studies Reveal Native-like ?-Sheet Structures in Transthyretin Amyloid. Biochemistry 55:5272-8
Aoto, Phillip C; Nishimura, Chiaki; Dyson, H Jane et al. (2014) Probing the non-native H helix translocation in apomyoglobin folding intermediates. Biochemistry 53:3767-80
Lim, Kwang Hun; Dyson, H Jane; Kelly, Jeffery W et al. (2013) Localized structural fluctuations promote amyloidogenic conformations in transthyretin. J Mol Biol 425:977-88
Meinhold, Derrick W; Wright, Peter E (2011) Measurement of protein unfolding/refolding kinetics and structural characterization of hidden intermediates by NMR relaxation dispersion. Proc Natl Acad Sci U S A 108:9078-83
Nishimura, Chiaki; Dyson, H Jane; Wright, Peter E (2010) Energetic frustration of apomyoglobin folding: role of the B helix. J Mol Biol 396:1319-28
Wright, Peter E; Dyson, H Jane (2009) Linking folding and binding. Curr Opin Struct Biol 19:31-8
Uzawa, Takanori; Nishimura, Chiaki; Akiyama, Shuji et al. (2008) Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast H/D exchange coupled with 2D NMR. Proc Natl Acad Sci U S A 105:13859-64

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