This research proposal involves measurements of absorption and secretion by the gastrointestinal tract in human subjects. We study normal people to elucidate physiology, and patients with intestinal diseases to elucidate pathophysiology. We use intestinal intubation with a triple-lumen, nonabsorbable marker technique to measure absorption in specific segments of the intestine. We use a one-meal balance method to measure absorption of dietary constituents. We are especially interested in chronic diarrheal diseases, malabsorption syndromes, mineral and nutrient absorption and malabsorption, antidiarrheal drugs, and fecal incontinence.
Our aim i s to expand knowledge of pathophysiology and to discover better diagnostic and therapeutic methods for people who suffer from gastrointestinal diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK037172-13
Application #
2518271
Study Section
Special Emphasis Panel (NSS)
Program Officer
Hamilton, Frank A
Project Start
1985-09-01
Project End
1998-08-31
Budget Start
1997-09-01
Budget End
1998-08-31
Support Year
13
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Baylor Research Institute
Department
Type
DUNS #
096997515
City
Dallas
State
TX
Country
United States
Zip Code
75204
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