Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK041557-18
Application #
7058225
Study Section
Special Emphasis Panel (NSS)
Program Officer
Carrington, Jill L
Project Start
1988-09-01
Project End
2008-04-30
Budget Start
2006-05-01
Budget End
2008-04-30
Support Year
18
Fiscal Year
2006
Total Cost
$439,721
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Cario, E; Gerken, G; Podolsky, D K (2007) Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 132:1359-74
Beck, P L; Xavier, R; Wong, J et al. (2004) Paradoxical roles of different nitric oxide synthase isoforms in colonic injury. Am J Physiol Gastrointest Liver Physiol 286:G137-47
Hisamatsu, Tadakazu; Suzuki, Manabu; Podolsky, Daniel K (2003) Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells. J Biol Chem 278:32962-8
Beck, Paul L; Rosenberg, Ian M; Xavier, Ramnik J et al. (2003) Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am J Pathol 162:597-608
Cario, Elke; Brown, Dennis; McKee, Mary et al. (2002) Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. Am J Pathol 160:165-73
Cario, E; Gerken, G; Podolsky, D K (2002) ""For whom the bell tolls!"" -- innate defense mechanisms and survival strategies of the intestinal epithelium against lumenal pathogens. Z Gastroenterol 40:983-90
Goke, M N; Cook, J R; Kunert, K S et al. (2001) Trefoil peptides promote restitution of wounded corneal epithelial cells. Exp Cell Res 264:337-44
Nishiyama, R; Sakaguchi, T; Kinugasa, T et al. (2001) Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions. J Biol Chem 276:35571-80
Cario, E; Podolsky, D K (2000) Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 68:7010-7
Podolsky, D K (2000) Review article: healing after inflammatory injury--coordination of a regulatory peptide network. Aliment Pharmacol Ther 14 Suppl 1:87-93

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