Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK045365-13
Application #
6781794
Study Section
Special Emphasis Panel (NSS)
Program Officer
Badman, David G
Project Start
1992-09-30
Project End
2007-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
13
Fiscal Year
2004
Total Cost
$580,094
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Hughey, Jeffery R; Du, Meijun; Li, Qiliang et al. (2012) A search for ? thalassemia mutations in 4000 year old ancient DNAs of Minoan Cretans. Blood Cells Mol Dis 48:7-10
Fang, Xiangdong; Yin, Wenxuan; Xiang, Ping et al. (2009) The higher structure of chromatin in the LCR of the beta-globin locus changes during development. J Mol Biol 394:197-208
Olave, Ivan A; Doneanu, Catalin; Fang, Xiangdong et al. (2007) Purification and identification of proteins that bind to the hereditary persistence of fetal hemoglobin -198 mutation in the gamma-globin gene promoter. J Biol Chem 282:853-62
Li, Qiliang; Fang, Xiangdong; Olave, Ivan et al. (2006) Transcriptional potential of the gamma-globin gene is dependent on the CACCC box in a developmental stage-specific manner. Nucleic Acids Res 34:3909-16
Yu, Man; Han, Hemei; Xiang, Ping et al. (2006) Autonomous silencing as well as competition controls gamma-globin gene expression during development. Mol Cell Biol 26:4775-81
Cao, Hua; Jung, Manfred; Stamatoyannopoulos, George (2005) Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce gamma gene expression in vivo. Exp Hematol 33:1443-9
Fang, Xiangdong; Sun, Jin; Xiang, Ping et al. (2005) Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture. Mol Cell Biol 25:7033-41
Xiang, Ping; Han, Hemei; Barkess, Grainne et al. (2005) Juxtaposition of the HPFH2 enhancer is not sufficient to reactivate the gamma-globin gene in adult erythropoiesis. Hum Mol Genet 14:3047-56
Cao, Hua; Stamatoyannopoulos, George; Jung, Manfred (2004) Induction of human gamma globin gene expression by histone deacetylase inhibitors. Blood 103:701-9
Fang, Xiangdong; Han, Hemei; Stamatoyannopoulos, George et al. (2004) Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression. J Biol Chem 279:5444-9

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