Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37ES002581-16
Application #
2153152
Study Section
Special Emphasis Panel (NSS)
Project Start
1981-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Michigan State University
Department
Pharmacology
Type
Schools of Veterinary Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Wagner, James G; Harkema, Jack R; Roth, Robert A (2002) Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. Shock 17:151-8
Wagner, J G; Roth, R A (2000) Neutrophil migration mechanisms, with an emphasis on the pulmonary vasculature. Pharmacol Rev 52:349-74
Wagner, J G; Roth, R A (1999) Neutrophil migration during endotoxemia. J Leukoc Biol 66:10-24
Wagner, J G; Driscoll, K E; Roth, R A (1999) Inhibition of pulmonary neutrophil trafficking during endotoxemia is dependent on the stimulus for migration. Am J Respir Cell Mol Biol 20:769-76
Schultze, A E; Roth, R A (1998) Chronic pulmonary hypertension--the monocrotaline model and involvement of the hemostatic system. J Toxicol Environ Health B Crit Rev 1:271-346
Lappin, P B; Ross, K L; King, L E et al. (1998) The response of pulmonary vascular endothelial cells to monocrotaline pyrrole: cell proliferation and DNA synthesis in vitro and in vivo. Toxicol Appl Pharmacol 150:37-48
Lappin, P B; Roth, R A (1997) Hypertrophy and prolonged DNA synthesis in smooth muscle cells characterize pulmonary arterial wall thickening after monocrotaline pyrrole administration to rats. Toxicol Pathol 25:372-80
Schultze, A E; Emeis, J J; Roth, R A (1996) Cellular fibronectin and von Willebrand factor concentrations in plasma of rats treated with monocrotaline pyrrole. Biochem Pharmacol 51:187-91
Hoorn, C M; Wagner, J G; Petry, T W et al. (1995) Toxicity of mitomycin C toward cultured pulmonary artery endothelium. Toxicol Appl Pharmacol 130:87-94
Boor, P J; Gotlieb, A I; Joseph, E C et al. (1995) Chemical-induced vasculature injury. Summary of the symposium presented at the 32nd annual meeting of the Society of Toxicology, New Orleans, Louisiana, March 1993. Toxicol Appl Pharmacol 132:177-95

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