Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37EY004171-15
Application #
2159026
Study Section
Special Emphasis Panel (NSS)
Project Start
1981-09-30
Project End
1999-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical College of Georgia (MCG)
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Augusta
State
GA
Country
United States
Zip Code
30912
Sharif, Naj A; Crider, Julie Y; Husain, Shahid et al. (2003) Human ciliary muscle cell responses to FP-class prostaglandin analogs: phosphoinositide hydrolysis, intracellular Ca2+ mobilization and MAP kinase activation. J Ocul Pharmacol Ther 19:437-55
Abdel-Latif, A A; Husain, S; Yousufzai, S Y (2000) Role of protein kinase C alpha and mitogen-activated protein kinases in endothelin-1-stimulation of cytosolic phospholipase A2 in iris sphincter smooth muscle. J Cardiovasc Pharmacol 36:S117-9
Yousufzai, S Y; Ali, N; Abdel-Latif, A A (1999) Effects of adrenomedullin on cyclic AMP formation and on relaxation in iris sphincter smooth muscle. Invest Ophthalmol Vis Sci 40:3245-53
Ding, K H; Latimer, A J; Abdel-Latif, A A (1999) Activation of particulate guanylyl cyclase by endothelins in cultured SV-40 transformed cat iris sphincter smooth muscle cells. Life Sci 64:161-74
Ding, K H; Ali, N; Abdel-Latif, A A (1999) Atrial natriuretic peptide provokes a dramatic increase in cyclic GMP formation and markedly inhibits muscarinic-stimulated Ca2+ mobilisation in SV-40 transformed cat iris sphincter smooth muscle (SV-CISM-2) cells. Cell Signal 11:87-94
Husain, S; Abdel-Latif, A A (1999) Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholipase A2 in cat iris sphincter smooth muscle cells. Biochem J 342 ( Pt 1):87-96
Yousufzai, S Y; Abdel-Latif, A A (1998) Tyrosine kinase inhibitors suppress prostaglandin F2alpha-induced phosphoinositide hydrolysis, Ca2+ elevation and contraction in iris sphincter smooth muscle. Eur J Pharmacol 360:185-93
Husain, S; Abdel-Latif, A A (1998) Role of protein kinase C alpha in endothelin-1 stimulation of cytosolic phospholipase A2 and arachidonic acid release in cultured cat iris sphincter smooth muscle cells. Biochim Biophys Acta 1392:127-44
Yousufzai, S Y; Abdel-Latif, A A (1998) Calcitonin gene-related peptide relaxes rabbit iris dilator smooth muscle via cyclic AMP-dependent mechanisms: cross-talk between the sensory and sympathetic nervous systems. Curr Eye Res 17:197-204
Ding, K H; Abdel-Latif, A A (1997) Actions of C-type natriuretic peptide and sodium nitroprusside on carbachol-stimulated inositol phosphate formation and contraction in ciliary and iris sphincter smooth muscles. Invest Ophthalmol Vis Sci 38:2629-38

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