Abstract

Our research focuses on three interrelated problems: (1) gene mapping of developmentally relevant genes, (2) transcriptional regulation of the transferrin receptor (TR) gene, and (3) the developmental role of the A- type homeobox genes in man and the laboratory mouse. Gene mapping will be used to determine if the linkage relationships of epigenetically relevant genes are conserved evolutionarily, and whether these linkage patterns are functionally significant. TR will be treated as a model system to study mechanisms which control cell division, and genes such as TR that are activated in dividing cells. The homeobox genes encode transcription factors which control the expression of genes relevant to the developmental process. Studies will be carried out to determine how these genes regulate themselves, how they respond to """"""""input"""""""" genes, and how they control the coordinated patterns of expression of """"""""target"""""""" genes. We see these three projects as interrelated, and we believe all three will contribute to a better understanding of the developmental process in mammals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM009966-30
Application #
3484086
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1975-09-01
Project End
1995-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
30
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Arts and Sciences
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Bentley, Kevin L; Stranford, Sharon; Liao, Shan et al. (2011) High endothelial venule reporter mice to probe regulation of lymph node vasculature. Adv Exp Med Biol 691:35-44
Lei, Haiyan; Juan, Aster H; Kim, Moo-Sang et al. (2007) Mouse naked cuticle 2 (mNkd2) as a direct transcriptional target of Hoxc8 in vivo. J Exp Zool A Ecol Genet Physiol 307:1-6
Chiba, Shigeru; Takeshita, Kenichi; Imai, Yoichi et al. (2003) Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. Proc Natl Acad Sci U S A 100:15577-82
Ledje, Christina; Kim, Chang-Bae; Ruddle, Francis H (2002) Characterization of Hox genes in the bichir, Polypterus palmas. J Exp Zool 294:107-11
Chiba, S; Takahashi, T; Takeshita, K et al. (1997) Selective expression of mRNA coding for the truncated form of erythropoietin receptor in hematopoietic cells and its decrease in patients with polycythemia vera. Blood 90:97-104
Bradshaw, M S; Ruddle, F H (1994) Identification of the murine Hox-c12 and Hox-c13 homeoboxes on yeast artificial chromosomes. Genomics 22:234-6
Ruddle, F H; Bentley, K L; Murtha, M T et al. (1994) Gene loss and gain in the evolution of the vertebrates. Dev Suppl :155-61
Ruddle, F H; Bartels, J L; Bentley, K L et al. (1994) Evolution of Hox genes. Annu Rev Genet 28:423-42
Lu, S; Wise, T L; Ruddle, F H (1994) Mouse homeobox gene Dbx: sequence, gene structure and expression pattern during mid-gestation. Mech Dev 47:187-95
Pendleton, J W; Nagai, B K; Murtha, M T et al. (1993) Expansion of the Hox gene family and the evolution of chordates. Proc Natl Acad Sci U S A 90:6300-4

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