Work on artificial enzymes will be pursued. This includes compounds combining cyclodextrins, pyridoxal or pyridoxamine with binding groups, such as cyclodextrins, macrocycles, or steroids; appropriate placement of basic catalytic groups will also be used to promote specific processes. The characteristic specificities of enzyme reactions--for substrate, for chemical reaction, for region of the substrate, and for stereochemistry of substrate and produce--will be mimicked. Work on thiamine related enzyme mimics will also be pursued, as will work on the synthesis and study of the hydrophobic cage molecules. Design of these syst;ems will be assisted by computer modeling methods. Work will be pursued on the design of catalysts that cleave RNA, using a newly developed assay technique. Studies of the catalysis of Diels-Alder reactions and related processes by hydrophobic effects and cage catalysts will be pursued, emphasizing selectivity. Work will also be directed at producing good mimics of peptide-cleaving and synthesizing enzymes.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM018754-28
Application #
3484261
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1977-01-01
Project End
1990-12-31
Budget Start
1989-01-01
Budget End
1989-12-31
Support Year
28
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Graduate Schools
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027