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Hughes, Louise M; Lanteri, Charlotte A; O'Neil, Michael T et al. (2011) Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance. Mol Biochem Parasitol 177:12-9
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Hughes, Louise M; Covian, Raul; Gribble, Gordon W et al. (2010) Probing binding determinants in center P of the cytochrome bc(1) complex using novel hydroxy-naphthoquinones. Biochim Biophys Acta 1797:38-43
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Castellani, Michela; Covian, Raul; Kleinschroth, Thomas et al. (2010) Direct demonstration of half-of-the-sites reactivity in the dimeric cytochrome bc1 complex: enzyme with one inactive monomer is fully active but unable to activate the second ubiquinol oxidation site in response to ligand binding at the ubiquinone reducti J Biol Chem 285:502-10
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Covian, Raul; Trumpower, Bernard L (2009) Ilicicolin Inhibition and Binding at Center N of the Dimeric Cytochrome bc1 Complex Reveal Electron Transfer and Regulatory Interactions between Monomers. J Biol Chem 284:8614-20
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Covian, Raul; Trumpower, Bernard L (2009) The rate-limiting step in the cytochrome bc1 complex (Ubiquinol-Cytochrome c Oxidoreductase) is not changed by inhibition of cytochrome b-dependent deprotonation: implications for the mechanism of ubiquinol oxidation at center P of the bc1 complex. J Biol Chem 284:14359-67
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Rottenberg, Hagai; Covian, Raul; Trumpower, Bernard L (2009) Membrane potential greatly enhances superoxide generation by the cytochrome bc1 complex reconstituted into phospholipid vesicles. J Biol Chem 284:19203-10
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Ding, Martina G; di Rago, Jean-Paul; Trumpower, Bernard L (2009) Combining Inhibitor Resistance-conferring Mutations in Cytochrome b Creates Conditional Synthetic Lethality in Saccharomyces cerevisiae. J Biol Chem 284:8478-85
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Zara, Vincenzo; Conte, Laura; Trumpower, Bernard L (2009) Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane. FEBS J 276:1900-14
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Covian, Raul; Trumpower, Bernard L (2008) Regulatory interactions in the dimeric cytochrome bc(1) complex: the advantages of being a twin. Biochim Biophys Acta 1777:1079-91
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Ding, Martina G; Butler, Christine A; Saracco, Scott A et al. (2008) Introduction of cytochrome b mutations in Saccharomyces cerevisiae by a method that allows selection for both functional and non-functional cytochrome b proteins. Biochim Biophys Acta 1777:1147-56
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