Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM020940-32
Application #
2173636
Study Section
Special Emphasis Panel (NSS)
Project Start
1979-01-01
Project End
1998-12-31
Budget Start
1995-03-01
Budget End
1998-12-31
Support Year
32
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Institute for Cancer Research
Department
Type
DUNS #
872612445
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Rose, Irwin A; Weaver, Todd M (2004) The role of the allosteric B site in the fumarase reaction. Proc Natl Acad Sci U S A 101:3393-7
Rose, Irwin A; Nowick, James S (2002) Methylglyoxal synthetase, enol-pyruvaldehyde, glutathione and the glyoxalase system. J Am Chem Soc 124:13047-52
Rose, I A (1998) How fumarase recycles after the malate --> fumarate reaction. Insights into the reaction mechanism. Biochemistry 37:17651-8
Rose, I A (1997) Restructuring the active site of fumarase for the fumarate to malate reaction. Biochemistry 36:12346-54
Rose, I A (1995) Partition analysis: detecting enzyme reaction cycle intermediates. Methods Enzymol 249:315-40
Rose, I A; Warms, J V; Yuan, R G (1993) Role of conformational change in the fumarase reaction cycle. Biochemistry 32:8504-11
Seeholzer, S H (1993) Phosphoglucose isomerase: a ketol isomerase with aldol C2-epimerase activity. Proc Natl Acad Sci U S A 90:1237-41
Rose, I A; Kuo, D J (1992) Role of CO2 in proton activation by histidine decarboxylase (pyruvoyl). Biochemistry 31:5887-92
Rose, I A; Warms, J V; Kuo, D J (1992) Proton transfer in catalysis by fumarase. Biochemistry 31:9993-9
Seeholzer, S H; Jaworowski, A; Rose, I A (1991) Enolpyruvate: chemical determination as a pyruvate kinase intermediate. Biochemistry 30:727-32

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