Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM021119-23
Application #
2173652
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-02-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
23
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
de Bruyn Kops, Anne; Guthrie, Christine (2018) Identification of the Novel Nup188-brr7 Allele in a Screen for Cold-Sensitive mRNA Export Mutants in Saccharomyces cerevisiae. G3 (Bethesda) 8:2991-3003
Nissen, Kelly E; Homer, Christina M; Ryan, Colm J et al. (2017) The histone variant H2A.Z promotes splicing of weak introns. Genes Dev 31:688-701
Ledoux, Sarah; Guthrie, Christine (2016) Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity. J Biol Chem 291:11954-65
Patrick, Kristin L; Ryan, Colm J; Xu, Jiewei et al. (2015) Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast. PLoS Genet 11:e1005074
Blanco, Mario R; Martin, Joshua S; Kahlscheuer, Matthew L et al. (2015) Single Molecule Cluster Analysis dissects splicing pathway conformational dynamics. Nat Methods 12:1077-84
Hadjivassiliou, Haralambos; Rosenberg, Oren S; Guthrie, Christine (2014) The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing. RNA 20:656-69
Ryan, Colm J; Roguev, Assen; Patrick, Kristin et al. (2012) Hierarchical modularity and the evolution of genetic interactomes across species. Mol Cell 46:691-704
Plocik, Alex M; Guthrie, Christine (2012) Diverse forms of RPS9 splicing are part of an evolving autoregulatory circuit. PLoS Genet 8:e1002620
Bergkessel, Megan; Whitworth, Gregg B; Guthrie, Christine (2011) Diverse environmental stresses elicit distinct responses at the level of pre-mRNA processing in yeast. RNA 17:1461-78
Mitrovich, Quinn M; Tuch, Brian B; De La Vega, Francisco M et al. (2010) Evolution of yeast noncoding RNAs reveals an alternative mechanism for widespread intron loss. Science 330:838-41

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