Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37GM023750-12
Application #
3484486
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1976-06-30
Project End
1992-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
12
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
School of Medicine & Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Huang, Jiansheng; Jia, Yuzhi; Fu, Tao et al. (2012) Sustained activation of PPAR? by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice. FASEB J 26:628-38
Vluggens, Aurore; Reddy, Janardan K (2012) Nuclear receptors and transcription factors in the development of fatty liver disease. Curr Drug Metab 13:1422-35
Bai, Liang; Jia, Yuzhi; Viswakarma, Navin et al. (2011) Transcription coactivator mediator subunit MED1 is required for the development of fatty liver in the mouse. Hepatology 53:1164-74
Huang, Jiansheng; Viswakarma, Navin; Yu, Songtao et al. (2011) Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice. Am J Pathol 179:703-13
Hall, Angela M; Brunt, Elizabeth M; Chen, Zhouji et al. (2010) Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice. J Lipid Res 51:554-63
Matsumoto, Kojiro; Huang, Jiansheng; Viswakarma, Navin et al. (2010) Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse. Carcinogenesis 31:318-25
Stumpf, Melanie; Yue, Xiaojing; Schmitz, Sandra et al. (2010) Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1. Proc Natl Acad Sci U S A 107:21541-6
Vluggens, Aurore; Andreoletti, Pierre; Viswakarma, Navin et al. (2010) Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. Lab Invest 90:696-708
Jia, Yuzhi; Viswakarma, Navin; Fu, Tao et al. (2009) Conditional ablation of mediator subunit MED1 (MED1/PPARBP) gene in mouse liver attenuates glucocorticoid receptor agonist dexamethasone-induced hepatic steatosis. Gene Expr 14:291-306
Li, Hui; Gade, Padmaja; Nallar, Shreeram C et al. (2008) The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma. J Biol Chem 283:13077-86

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