Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM024658-26
Application #
2174297
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1977-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
26
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Purdue University
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Sinha, Sangita C; Krahn, Joseph; Shin, Byung Sik et al. (2003) The purine repressor of Bacillus subtilis: a novel combination of domains adapted for transcription regulation. J Bacteriol 185:4087-98
Bera, Aloke Kumar; Zhu, Jianghai; Zalkin, Howard et al. (2003) Functional dissection of the Bacillus subtilis pur operator site. J Bacteriol 185:4099-109
Weng, M; Zalkin, H (2000) Mutations in the Bacillus subtilis purine repressor that perturb PRPP effector function in vitro and in vivo. Curr Microbiol 41:56-9
Bera, A K; Smith, J L; Zalkin, H (2000) Dual role for the glutamine phosphoribosylpyrophosphate amidotransferase ammonia channel. Interdomain signaling and intermediate channeling. J Biol Chem 275:7975-9
Bera, A K; Chen, S; Smith, J L et al. (2000) Temperature-dependent function of the glutamine phosphoribosylpyrophosphate amidotransferase ammonia channel and coupling with glycinamide ribonucleotide synthetase in a hyperthermophile. J Bacteriol 182:3734-9
Bera, A K; Chen, S; Smith, J L et al. (1999) Interdomain signaling in glutamine phosphoribosylpyrophosphate amidotransferase. J Biol Chem 274:36498-504
Li, S; Smith, J L; Zalkin, H (1999) Mutational analysis of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase propeptide processing. J Bacteriol 181:1403-8
Rappu, P; Shin, B S; Zalkin, H et al. (1999) A role for a highly conserved protein of unknown function in regulation of Bacillus subtilis purA by the purine repressor. J Bacteriol 181:3810-5
Sinha, S; Rappu, P; Lange, S C et al. (1999) Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family. Proc Natl Acad Sci U S A 96:13074-9
Lu, F; Schumacher, M A; Arvidson, D N et al. (1998) Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. Biochemistry 37:971-82

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