Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM026259-19
Application #
2174675
Study Section
Special Emphasis Panel (NSS)
Project Start
1990-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Jay, Kyle A; Smith, Dana L; Blackburn, Elizabeth H (2016) Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins. Mol Cell Biol 36:1908-19
Xie, Zhengwei; Jay, Kyle A; Smith, Dana L et al. (2015) Early telomerase inactivation accelerates aging independently of telomere length. Cell 160:928-939
Blackburn, Elizabeth H; Epel, Elissa S; Lin, Jue (2015) Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science 350:1193-8
Makovets, Svetlana; Blackburn, Elizabeth H (2009) DNA damage signalling prevents deleterious telomere addition at DNA breaks. Nat Cell Biol 11:1383-6
Seidel, Jeffrey J; Anderson, Carol M; Blackburn, Elizabeth H (2008) A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response. Mol Cell Biol 28:5736-46
Makovets, Svetlana; Williams, Tanya L; Blackburn, Elizabeth H (2008) The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase. Genetics 178:245-57
Hsu, Min; McEachern, Michael J; Dandjinou, Alain T et al. (2007) Telomerase core components protect Candida telomeres from aberrant overhang accumulation. Proc Natl Acad Sci U S A 104:11682-7
Epel, Elissa S; Lin, Jue; Wilhelm, Frank H et al. (2006) Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 31:277-87
Blackburn, Elizabeth H (2005) Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett 579:859-62
Makovets, Svetlana; Herskowitz, Ira; Blackburn, Elizabeth H (2004) Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Mol Cell Biol 24:4019-31

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