Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM027608-28
Application #
2174947
Study Section
Special Emphasis Panel (NSS)
Project Start
1980-01-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
28
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Motyka, Shawn A; Zhao, Zhixing; Gull, Keith et al. (2004) Integration of pZJM library plasmids into unexpected locations in the Trypanosoma brucei genome. Mol Biochem Parasitol 134:163-7
Saxowsky, Tina T; Choudhary, Gunjan; Klingbeil, Michele M et al. (2003) Trypanosoma brucei has two distinct mitochondrial DNA polymerase beta enzymes. J Biol Chem 278:49095-101
Saxowsky, Tina T; Matsumoto, Yoshihiro; Englund, Paul T (2002) The mitochondrial DNA polymerase beta from Crithidia fasciculata has 5'-deoxyribose phosphate (dRP) lyase activity but is deficient in the release of dRP. J Biol Chem 277:37201-6
Grams, Jayleen; Morris, James C; Drew, Mark E et al. (2002) A trypanosome mitochondrial RNA polymerase is required for transcription and replication. J Biol Chem 277:16952-9
Lukes, Julius; Guilbride, D Lys; Votypka, Jan et al. (2002) Kinetoplast DNA network: evolution of an improbable structure. Eukaryot Cell 1:495-502
Wang, Zefeng; Drew, Mark E; Morris, James C et al. (2002) Asymmetrical division of the kinetoplast DNA network of the trypanosome. EMBO J 21:4998-5005
Klingbeil, Michele M; Motyka, Shawn A; Englund, Paul T (2002) Multiple mitochondrial DNA polymerases in Trypanosoma brucei. Mol Cell 10:175-86
Morris, J C; Wang, Z; Drew, M E et al. (2001) Inhibition of bloodstream form Trypanosoma brucei gene expression by RNA interference using the pZJM dual T7 vector. Mol Biochem Parasitol 117:111-3
Morris, J C; Drew, M E; Klingbeil, M M et al. (2001) Replication of kinetoplast DNA: an update for the new millennium. Int J Parasitol 31:453-8
Klingbeil, M M; Drew, M E; Liu, Y et al. (2001) Unlocking the secrets of trypanosome kinetoplast DNA network replication. Protist 152:255-62

Showing the most recent 10 out of 48 publications