Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM030301-15
Application #
2175739
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1982-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Brown University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912

  Publications

Pemberton, Travis A; Chen, Mengbin; Harris, Golda G et al. (2017) Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. Biochemistry 56:2010-2023
Chou, Wayne Kw; Gould, Colin A; Cane, David E (2017) Incubation of 2-methylisoborneol synthase with the intermediate analog 2-methylneryl diphosphate. J Antibiot (Tokyo) 70:625-631
Blank, Patrick N; Barrow, Golda H; Chou, Wayne K W et al. (2017) Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. Biochemistry 56:5798-5811
Li, Zhenqiu; Gao, Ruiping; Hao, Qinggang et al. (2016) The T296V Mutant of Amorpha-4,11-diene Synthase Is Defective in Allylic Diphosphate Isomerization but Retains the Ability To Cyclize the Intermediate (3R)-Nerolidyl Diphosphate to Amorpha-4,11-diene. Biochemistry 55:6599-6604
Chen, Mengbin; Chou, Wayne K W; Toyomasu, Tomonobu et al. (2016) Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase. ACS Chem Biol 11:889-99
Chen, Ke; Wu, Shiwen; Zhu, Lu et al. (2016) Substitution of a Single Amino Acid Reverses the Regiospecificity of the Baeyer-Villiger Monooxygenase PntE in the Biosynthesis of the Antibiotic Pentalenolactone. Biochemistry 55:6696-6704
Duan, Lian; Jogl, Gerwald; Cane, David E (2016) The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines Mechanism. J Am Chem Soc 138:12678-89
Chen, Mengbin; Chou, Wayne K W; Al-Lami, Naeemah et al. (2016) Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase. Biochemistry 55:2864-74
Johnson, Mark E; Shon, Judy; Guan, Brian M et al. (2016) Fluorocarbon Modified Low-Molecular-Weight Polyethylenimine for siRNA Delivery. Bioconjug Chem 27:1784-8
Yamada, Yuuki; Arima, Shiho; Nagamitsu, Tohru et al. (2015) Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host. J Antibiot (Tokyo) 68:385-94

Showing the most recent 10 out of 75 publications