Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM031354-19
Application #
6477866
Study Section
Special Emphasis Panel (NSS)
Program Officer
Jones, Warren
Project Start
1983-03-01
Project End
2007-11-30
Budget Start
2002-12-06
Budget End
2003-11-30
Support Year
19
Fiscal Year
2003
Total Cost
$203,420
Indirect Cost

  Institution

Name
Washington State University
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164

  Publications

Srividya, Narayanan; Davis, Edward M; Croteau, Rodney B et al. (2015) Functional analysis of (4S)-limonene synthase mutants reveals determinants of catalytic outcome in a model monoterpene synthase. Proc Natl Acad Sci U S A 112:3332-7
Karp, Frank; Zhao, Yuxin; Santhamma, Bindu et al. (2007) Inhibition of monoterpene cyclases by inert analogues of geranyl diphosphate and linalyl diphosphate. Arch Biochem Biophys 468:140-6
Hyatt, David C; Youn, Buhyun; Zhao, Yuxin et al. (2007) Structure of limonene synthase, a simple model for terpenoid cyclase catalysis. Proc Natl Acad Sci U S A 104:5360-5
Jin, Qingwu; Williams, David C; Hezari, Mehri et al. (2005) Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling. J Org Chem 70:4667-75
Hyatt, David C; Croteau, Rodney (2005) Mutational analysis of a monoterpene synthase reaction: altered catalysis through directed mutagenesis of (-)-pinene synthase from Abies grandis. Arch Biochem Biophys 439:222-33
Jin, Yinghua; Williams, David C; Croteau, Rodney et al. (2005) Taxadiene synthase-catalyzed cyclization of 6-fluorogeranylgeranyl diphosphate to 7-fluoroverticillenes. J Am Chem Soc 127:7834-42
Katoh, Sadanobu; Hyatt, David; Croteau, Rodney (2004) Altering product outcome in Abies grandis (-)-limonene synthase and (-)-limonene/(-)-alpha-pinene synthase by domain swapping and directed mutagenesis. Arch Biochem Biophys 425:65-76
Peters, Reuben J; Carter, Ora A; Zhang, Yan et al. (2003) Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations. Biochemistry 42:2700-7
Phillips, Michael A; Wildung, Mark R; Williams, David C et al. (2003) cDNA isolation, functional expression, and characterization of (+)-alpha-pinene synthase and (-)-alpha-pinene synthase from loblolly pine (Pinus taeda): stereocontrol in pinene biosynthesis. Arch Biochem Biophys 411:267-76
Peters, Reuben J; Croteau, Rodney B (2003) Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases. Arch Biochem Biophys 417:203-11

Showing the most recent 10 out of 78 publications